Effectiveness of Brassica oleracea L. Var. Italica on Liver Repair of Mice Exposed to the Heavy Metal Pb

Abstract

Lead toxicity has a broad impact on human health, specifically on the liver. Lead can neutralize antioxidants so there is a risk of increasing the number of free radicals and can damage the liver. Therefore, the amount of antioxidants in the body can be a factor in preventing damage to the body due to lead. This research was carried out to determine the effectiveness of Broccoli extract in repairing the livers of mice exposed to the heavy metal Pb Acetate. This research is experimental research with a Posttest-only Control Group Design. The research object was mice (Mus musculus) which were divided into 5 groups. Data was collected by observing liver tissue objects using histology techniques. The research results showed the good effectiveness of broccoli extract (Brassica oleracea L. Var. Italica) in improving the liver of mice. In the 50% dose group, hepatocytes turned normal. Fatty degeneration occurred in groups with a dose of 75% and a dose of 100%. From these results, it can be said that broccoli extract can be an alternative for treating liver damage due to exposure to heavy metals. However, you need to pay attention to the dosage used.